This preliminary report details the results of looking for pathway enrichment in each of the groups of genes produced by hierarchical clustering of the drug perturbations. I’ve cut the the data into 25, but this value can be changed if we decide on a different value. Otherwise, this analysis focuses on enriched pathways in the KEGG database. Specifically, this analysis uses the C2 KEGG segment from: https://www.gsea-msigdb.org/gsea/msigdb.

As for this report, the panel on the left is sorted by the number of dark kinases in the cluster and displays both the number of pathway hits and dark kinases in the cluster. The number of each cluster is arbitrary. The entry for each cluster displays the kinases associated with the cluster along with the number of non-kinases genes. Below this table are the pathways that passed the enrichment analysis at the 0.01 false discovery rate level. I also corrected for running this analysis for all 25 clusters.

Overall Enrichment Stats

Overall, 76 pathways are enriched in at least one of the following clusters. Of these pathways 52 are only hit once. The following pathways are seen in two or more clusters:

Num: 12 (Pathways: 14 DK: 19)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (19) CAMK1D, CAMKV, CDKL3, DYRK1B, LMTK2, LMTK3, MAP3K15, MAPK15, MARK1, MKNK1, NEK5, PIK3C2B, PIP5K1B, SBK1, SCYL2, STK3, TESK2, TSSK1B, VRK3
Light Kinase (46) ACVR1C, ACVR2A, ACVRL1, ANKK1, BMP2K, BMX, CAMK2B, CAMK4, CDK9, CSF1R, DAPK1, DAPK2, DCLK1, EPHA6, EPHB2, EPHB3, FGFR1, FGFR2, FGFR3, FGFR4, FLT4, HCK, ITK, JAK2, KALRN, KSR1, KSR2, MAP2K3, MAP2K6, MAP4K1, MAPK10, MAPK11, MAST1, MATK, PI4KAP2, PRKCG, PRKCZ, PRKD2, PTK2, RPS6KA3, SGK2, SRPK2, STK26, STYK1, TAF1L, TXK
Non-kinase Count 1748
label pval fdr signature geneset overlap hits
KEGG_CELL_ADHESION_MOLECULES_CAMS 0.0e+00 0.0e+00 1813 133 32 CD22,CD34,CD40,CD6,CD86,CDH1,CDH15,CDH2,CDH3,CLDN10,CLDN23,CNTN1,ESAM,HLA-DPB1,ICAM2,ITGA6,ITGAL,ITGAM,ITGB7,JAM3,NCAM1,NECTIN2,NEO1,NFASC,NRXN1,NRXN2,NRXN3,OCLN,SELL,SELPLG,SPN,VCAN
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 0.0e+00 0.0e+00 1813 272 42 ADCYAP1R1,ADRA1A,AVPR1A,CHRM4,CHRNA10,CHRNA7,CHRNB2,CHRNB4,DRD2,DRD4,FPR2,GABRA1,GABRA6,GABRB2,GABRD,GABRP,GABRQ,GHR,GLRA3,GRID1,GRIK4,GRIK5,GRIN1,GRM7,HTR2A,LTB4R2,MC2R,NMUR1,NPFFR1,NPFFR2,NPY1R,OPRD1,OPRK1,P2RX7,P2RY1,P2RY8,PTAFR,PTGER4,S1PR3,S1PR5,SSTR2,VIPR2
KEGG_MAPK_SIGNALING_PATHWAY 0.0e+00 0.0e+00 1813 267 35 CACNA1G,CACNA1I,CACNA2D1,CACNA2D2,CACNB2,CACNG7,CHP2,DUSP1,DUSP9,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,GRB2,IL1R2,JUN,MAP2K3,MAP2K6,MAP4K1,MAPK10,MAPK11,MAPK8IP1,MAPK8IP2,MKNK1,NFATC4,PLA2G2D,PLA2G4A,PLA2G4E,PRKCG,RASGRF1,RPS6KA3,STK3
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 2.0e-07 1813 213 28 ACTN2,APC2,CFL2,CHRM4,CYFIP2,ENAH,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FGFR4,ITGA6,ITGAL,ITGAM,ITGAX,ITGB7,MYH14,MYL2,NCKAP1L,PIK3R5,PIP4K2A,PIP5K1B,PTK2,SCIN,VAV1,WAS
KEGG_CALCIUM_SIGNALING_PATHWAY 0.0e+00 3.0e-07 1813 177 25 ADCY4,ADRA1A,ATP2A3,ATP2B2,AVPR1A,CACNA1G,CACNA1I,CAMK2B,CAMK4,CD38,CHP2,CHRNA7,GNAL,GRIN1,HTR2A,LTB4R2,NOS1,NOS2,P2RX7,PDE1B,PLCD1,PRKCG,PTAFR,RYR1,RYR3
KEGG_AXON_GUIDANCE 0.0e+00 3.0e-07 1813 129 21 CFL2,CHP2,DCC,DPYSL5,EFNA2,EPHA6,EPHB2,EPHB3,LRRC4C,NCK2,NFATC4,NTN1,PTK2,ROBO1,SEMA4D,SEMA5B,SEMA7A,SLIT1,SLIT3,SRGAP3,UNC5B
KEGG_TIGHT_JUNCTION 3.0e-07 8.6e-06 1813 132 19 ACTN2,CGN,CLDN10,CLDN23,IGSF5,JAM3,MAGI2,MYH14,MYH15,MYL2,OCLN,PARD6G,PPP2R2C,PRKCG,PRKCZ,RAB3B,SPTAN1,SYMPK,TJP1
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 5.0e-07 1.2e-05 1813 265 28 ACVR2A,ACVRL1,CCL26,CCR6,CD40,CD70,CSF1R,CX3CR1,CXCR2,EDA,FLT4,GHR,IFNLR1,IL11,IL12A,IL19,IL1R2,IL23R,IL2RB,IL3RA,IL7,INHBB,INHBC,NGFR,TNFRSF19,TNFRSF8,TNFSF10,TNFSF15
KEGG_O_GLYCAN_BIOSYNTHESIS 8.0e-07 1.6e-05 1813 30 9 B4GALT5,GALNT10,GALNT13,GALNT16,GALNT6,GALNT9,GCNT3,GCNT4,ST3GAL2
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.0e-06 1.9e-05 1813 116 17 ACTN2,CLDN10,CLDN23,CYBB,ESAM,ITGAL,ITGAM,ITK,JAM3,MAPK11,MYL2,OCLN,PIK3R5,PRKCG,PTK2,TXK,VAV1
KEGG_PATHWAYS_IN_CANCER 3.4e-06 5.8e-05 1813 325 30 APC2,CBL,CDH1,CDKN2A,CEBPA,CSF1R,DAPK1,DAPK2,DCC,FGF14,FGF18,FGF21,FGFR1,FGFR2,FGFR3,FZD9,GLI1,GRB2,ITGA6,JUN,LAMA4,MAPK10,NKX3-1,NOS2,PIK3R5,PRKCG,PTK2,RARB,TCF7,TCF7L1
KEGG_CARDIAC_MUSCLE_CONTRACTION 4.4e-06 6.8e-05 1813 78 13 ATP1A3,ATP1B1,ATP1B2,CACNA2D1,CACNA2D2,CACNB2,CACNG7,COX6B2,COX7B2,MYL2,TNNI3,TNNT2,UQCRHL
KEGG_NATURAL_KILLER_CELL_MEDIATED_CYTOTOXICITY 1.0e-05 1.5e-04 1813 137 17 CHP2,GRB2,ICAM2,ITGAL,KLRC1,KLRC3,NFATC4,PIK3R5,PRKCG,RAET1G,SH2D1A,SHC4,TNFSF10,ULBP1,ULBP2,ULBP3,VAV1
KEGG_HEMATOPOIETIC_CELL_LINEAGE 1.5e-05 2.0e-04 1813 87 13 CD1D,CD22,CD34,CD38,CD3D,CR2,CSF1R,IL11,IL1R2,IL3RA,IL7,ITGA6,ITGAM

Num: 11 (Pathways: 15 DK: 14)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (14) CDK19, DSTYK, HIPK3, LRRK1, MAP3K10, MARK4, NEK11, PIP4K2C, PIP5K1C, RPS6KC1, SBK3, SRPK3, STK38L, TTBK2
Light Kinase (32) AAK1, ABR, ACVR1, BRD2, CAMK2D, CSNK1D, DGKD, EIF2AK3, FRK, GSK3B, HK1, ILK, INSR, JAK1, LATS2, MAP2K2, MAP3K8, MAPK1, MAPKAPK2, MST1R, MYLK3, MYLK4, NRBP1, NUAK1, PEAK1, PI4K2A, PINK1, SIK3, TAOK3, TGFBR1, TRPM7, ULK1
Non-kinase Count 1183
label pval fdr signature geneset overlap hits
KEGG_LYSOSOME 0.0e+00 0.0e+00 1229 121 25 ATP6AP1,CD164,CD63,CLN3,CLTCL1,CTNS,CTSA,CTSB,CTSD,CTSF,DNASE2,GAA,GALNS,GNS,IGF2R,LAMP2,MANBA,MCOLN1,NEU1,PLA2G15,PSAP,SCARB2,SLC17A5,SMPD1,TPP1
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 0.0e+00 1229 213 28 ACTG1,ARHGEF12,ARHGEF6,ARPC3,BAIAP2,CDC42,CRK,CYFIP1,FGF13,IQGAP1,ITGA1,ITGA7,ITGAV,ITGB1,MAP2K2,MAPK1,MSN,MYL12A,MYL12B,MYL5,MYLK3,PIP4K2C,PIP5K1C,RHOA,RRAS,RRAS2,TIAM2,WASL
KEGG_FOCAL_ADHESION 0.0e+00 0.0e+00 1229 199 25 ACTG1,ARHGAP5,CDC42,COL11A2,COL6A1,COL6A2,CRK,CTNNB1,GSK3B,HGF,ILK,ITGA1,ITGA7,ITGAV,ITGB1,LAMC1,MAPK1,MYL12A,MYL12B,MYL5,MYLK3,PIP5K1C,RAPGEF1,RHOA,THBS3
KEGG_STEROID_BIOSYNTHESIS 0.0e+00 0.0e+00 1229 17 9 CYP51A1,DHCR24,EBP,FDFT1,LSS,MSMO1,NSDHL,SC5D,SOAT1
KEGG_PATHWAYS_IN_CANCER 2.0e-07 6.6e-06 1229 325 26 ARNT,ARNT2,CCDC6,CDC42,CRK,CSF2RA,CTNNA1,CTNNB1,FGF13,FZD8,GSK3B,HGF,ITGAV,ITGB1,JAK1,LAMC1,MAP2K2,MAPK1,NCOA4,PAX8,RALGDS,RHOA,STAT5B,TGFBR1,TRAF6,WNT5B
KEGG_ADHERENS_JUNCTION 2.0e-07 6.6e-06 1229 73 12 ACTG1,BAIAP2,CDC42,CTNNA1,CTNNB1,INSR,IQGAP1,MAPK1,RHOA,SORBS1,TGFBR1,WASL
KEGG_ENDOCYTOSIS 6.0e-07 1.7e-05 1229 181 18 ARAP1,ASAP2,CDC42,CHMP1B,CHMP2A,CLTCL1,CXCR4,DAB2,EPS15,GIT2,MVB12B,PIP5K1C,PSD4,RAB11FIP5,RAB31,RAB5B,SH3GLB1,TRAF6
KEGG_AXON_GUIDANCE 7.0e-07 1.7e-05 1229 129 15 ARHGEF12,CDC42,CHP1,CXCR4,EFNA1,EFNB3,GNAI2,GSK3B,ITGB1,MAPK1,NFAT5,PLXNA3,RHOA,SEMA4B,SEMA6C
KEGG_TERPENOID_BACKBONE_BIOSYNTHESIS 9.0e-07 1.9e-05 1229 15 6 ACAT1,ACAT2,FDPS,HMGCR,HMGCS1,IDI1
KEGG_LEUKOCYTE_TRANSENDOTHELIAL_MIGRATION 1.1e-06 2.0e-05 1229 116 14 ACTG1,ARHGAP5,CDC42,CTNNA1,CTNNB1,CXCR4,GNAI2,ITGB1,MSN,MYL12A,MYL12B,MYL5,NCF2,RHOA
KEGG_TIGHT_JUNCTION 5.1e-06 8.6e-05 1229 132 14 ACTG1,CDC42,CTNNA1,CTNNB1,EXOC3,EXOC4,GNAI2,MYL12A,MYL12B,MYL5,PATJ,RHOA,RRAS,RRAS2
KEGG_FATTY_ACID_METABOLISM 7.3e-06 1.1e-04 1229 42 8 ACAT1,ACAT2,ACOX1,ACSL1,ADH5,EHHADH,HADHA,HADHB
KEGG_PATHOGENIC_ESCHERICHIA_COLI_INFECTION 8.5e-06 1.2e-04 1229 56 9 ACTG1,ARPC3,CDC42,CTNNB1,ITGB1,LY96,RHOA,WASL,YWHAZ
KEGG_ALZHEIMERS_DISEASE 1.6e-05 2.1e-04 1229 165 15 ADAM17,APP,CAPN1,CHP1,COX6A1,COX6C,EIF2AK3,GRIN2D,GSK3B,ITPR2,LRP1,MAPK1,MT-ATP6,MT-ATP8,PSEN1
KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 2.8e-05 3.5e-04 1229 115 12 ADCY2,ARHGEF12,CALCRL,CALD1,GNAS,ITPR2,MAP2K2,MAPK1,MYL6,MYL6B,MYLK3,RHOA

Num: 7 (Pathways: 0 DK: 11)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (11) CAMKK1, MAST2, NEK1, NEK4, PAN3, PHKG2, PIP5K1A, TAOK1, TESK1, TLK1, ULK4
Light Kinase (20) ADPGK, BAZ1A, BAZ1B, CAMK2A, CDK3, CSK, DDR2, DGKE, GRK2, HSPB8, MAP3K6, MAPK7, MLKL, PASK, PI4KB, PIK3C3, SLK, STK4, TPTEP2-CSNK1E, TTN
Non-kinase Count 868
label pval fdr signature geneset overlap hits

Num: 2 (Pathways: 3 DK: 10)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (10) BRSK1, CDK11B, CDK16, CSNK1G3, MARK3, PHKG1, RIOK1, RIOK2, RPS6KL1, VRK2
Light Kinase (22) CASK, CDK8, CSNK2A1, DGKG, EIF2AK2, FLT1, GAK, HUNK, MAP3K4, MAPK9, MARK2, PAK4, PDPK2P, PIM1, PLK2, PRKAA1, RPS6KB1, SGK3, TBK1, TEX14, TRIB3, TRIM33
Non-kinase Count 983
label pval fdr signature geneset overlap hits
KEGG_RIBOSOME 0 0e+00 1015 88 70 FAU,RPL10,RPL10A,RPL11,RPL12,RPL13,RPL13A,RPL14,RPL15,RPL17,RPL18,RPL18A,RPL19,RPL22L1,RPL23,RPL23A,RPL26,RPL27,RPL27A,RPL28,RPL29,RPL3,RPL30,RPL31,RPL32,RPL34,RPL35,RPL35A,RPL36,RPL36A,RPL37,RPL37A,RPL38,RPL39,RPL4,RPL5,RPL6,RPL7,RPL8,RPL9,RPLP0,RPLP1,RPLP2,RPS10,RPS11,RPS12,RPS13,RPS15A,RPS16,RPS18,RPS19,RPS2,RPS20,RPS21,RPS23,RPS24,RPS25,RPS27,RPS27A,RPS28,RPS29,RPS3,RPS3A,RPS4X,RPS5,RPS6,RPS8,RPS9,RPSA,UBA52
KEGG_SPLICEOSOME 0 0e+00 1015 127 18 BUD31,CTNNBL1,CWC15,MAGOH,PLRG1,PPIE,PRPF3,SF3A1,SF3B6,SMNDC1,SNRNP27,SNRPB2,SNU13,SRSF1,SRSF3,SRSF7,U2AF1,USP39
KEGG_PROTEASOME 0 1e-07 1015 46 11 PSMA4,PSMA5,PSMA6,PSMB3,PSMC5,PSMD11,PSMD13,PSMD14,PSMD3,PSMD4,PSME4

Num: 1 (Pathways: 7 DK: 9)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (9) ADCK1, ADCK5, CDC42BPG, COQ8B, MAST3, NEK9, PRAG1, STK32A, TAOK2
Light Kinase (28) BCR, BRD3, CKMT1A, CKMT1B, EIF2AK1, EPHA7, EPHB6, ERBB4, KDR, LIMK1, MAP3K13, MAP3K5, MAP4K2, MINK1, PRKACA, PRKCA, PRKCH, PRKX, PTK2B, ROCK2, RPS6KA2, SGK1, STK11, STK38, TGFBR2, TNK2, TRIM66, UHMK1
Non-kinase Count 1088
label pval fdr signature geneset overlap hits
KEGG_PEROXISOME 0.0e+00 4.0e-07 1125 78 14 ABCD2,ABCD3,AMACR,CRAT,CROT,FAR2,GSTK1,IDH2,MLYCD,PEX1,PEX2,PEX7,PMVK,PXMP4
KEGG_ENDOCYTOSIS 0.0e+00 2.1e-06 1125 181 19 ACAP3,ADRB1,ADRB2,AP2A2,ARRB1,ARRB2,ASAP3,DNAJC6,DNM3,ERBB4,HSPA2,IQSEC1,KDR,LDLRAP1,PARD6A,PSD3,RAB11FIP1,RAB4A,SH3GLB2
KEGG_PATHWAYS_IN_CANCER 0.0e+00 2.1e-06 1125 325 26 APPL1,BCR,CASP9,COL4A1,COL4A2,FGF12,FGF5,FN1,FOXO1,FZD1,FZD3,FZD4,GLI2,GLI3,HIF1A,ITGA3,JUP,LAMA1,LAMA5,PRKCA,PTCH1,RASSF5,RUNX1T1,STAT1,TGFBR2,WNT11
KEGG_WNT_SIGNALING_PATHWAY 3.0e-07 1.5e-05 1125 150 16 CTNNBIP1,CXXC4,FZD1,FZD3,FZD4,LRP5,PLCB2,PPP2R5A,PRICKLE1,PRICKLE2,PRKACA,PRKCA,PRKX,ROCK2,VANGL1,WNT11
KEGG_AXON_GUIDANCE 1.4e-06 5.2e-05 1125 129 14 ABLIM1,ABLIM2,EFNB2,EPHA7,EPHB6,LIMK1,ROBO2,ROCK2,SEMA3F,SEMA4F,SEMA4G,SEMA5A,SEMA6D,SRGAP1
KEGG_VIBRIO_CHOLERAE_INFECTION 3.1e-06 9.5e-05 1125 54 9 ADCY9,ATP6V0A1,ATP6V0E2,ATP6V1E2,ATP6V1G2,MUC2,PRKACA,PRKCA,PRKX
KEGG_SULFUR_METABOLISM 6.3e-06 1.7e-04 1125 13 5 BPNT1,CHST12,PAPSS1,SULT1A4,SUOX

Num: 4 (Pathways: 11 DK: 9)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (9) CDK11A, CDK12, CDKL1, COQ8A, CSNK1G1, CSNK2A2, NEK7, PDIK1L, TLK2
Light Kinase (18) ARAF, AURKB, BUB1, CDK1, CDK2, CHEK1, DGKZ, GSK3A, GTF2F1, IRAK3, MASTL, MELK, NEK2, PAK1, PAK2, PLK4, SRPK1, YES1
Non-kinase Count 1129
label pval fdr signature geneset overlap hits
KEGG_SPLICEOSOME 0.0e+00 0.0e+00 1156 127 29 ALYREF,BCAS2,CHERP,HNRNPA3,HNRNPK,HNRNPU,ISY1,LSM8,MAGOHB,PHF5A,PQBP1,PRPF38A,PUF60,RBM17,RBM25,RBM8A,RBMX,SF3A3,SNRPA,SNRPA1,SNRPB,SNW1,SRSF4,SYF2,TCERG1,THOC1,U2SURP,WBP11,XAB2
KEGG_CELL_CYCLE 0.0e+00 0.0e+00 1156 124 22 BUB1,CCNA2,CCNB1,CCNB2,CDC25A,CDC25C,CDC27,CDC6,CDK1,CDK2,CHEK1,CREBBP,CUL1,E2F3,ESPL1,MCM7,ORC6,RAD21,SFN,SMAD4,SMC1B,STAG2
KEGG_RNA_DEGRADATION 0.0e+00 0.0e+00 1156 59 15 C1D,CNOT10,CNOT2,CNOT6,CNOT6L,CNOT9,DIS3,EXOSC10,EXOSC3,EXOSC4,EXOSC5,EXOSC9,LSM8,PAPOLA,TENT4A
KEGG_PROTEASOME 0.0e+00 0.0e+00 1156 46 13 PSMA1,PSMA3,PSMA7,PSMB2,PSMB5,PSMB6,PSMB7,PSMC1,PSMC2,PSMC3,PSMC6,PSMD8,PSME2
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0.0e+00 1.0e-07 1156 134 18 CDC27,COP1,CUL1,CUL3,CUL4A,DDB1,ERCC8,ITCH,RCHY1,RNF7,TRIP12,UBA2,UBA6,UBE2C,UBE2I,UBE2M,UBE2Z,XIAP
KEGG_HUNTINGTONS_DISEASE 0.0e+00 1.4e-06 1156 180 19 AP2B1,ATP5F1B,ATP5PB,CASP3,CLTA,COX5A,CREB1,CREBBP,CYC1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,NRF1,SLC25A5,UQCRC2,UQCRH,VDAC1
KEGG_ALZHEIMERS_DISEASE 3.0e-07 7.9e-06 1156 165 17 APH1A,ATP5F1B,ATP5PB,BID,CASP3,COX5A,CYC1,HSD17B10,NAE1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,PPP3R1,UQCRC2,UQCRH
KEGG_OOCYTE_MEIOSIS 3.0e-07 7.9e-06 1156 112 14 BUB1,CCNB1,CCNB2,CDC25C,CDC27,CDK1,CDK2,CUL1,ESPL1,PPP2R1B,PPP2R5D,PPP2R5E,PPP3R1,SMC1B
KEGG_PARKINSONS_DISEASE 1.7e-06 3.6e-05 1156 128 14 ATP5F1B,ATP5PB,CASP3,COX5A,CYC1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,SLC25A5,UQCRC2,UQCRH,VDAC1
KEGG_OXIDATIVE_PHOSPHORYLATION 2.3e-06 4.3e-05 1156 131 14 ATP5F1B,ATP5MG,ATP5PB,ATP6V0A2,ATP6V1G1,COX5A,CYC1,NDUFA10,NDUFA9,NDUFS3,NDUFS7,NDUFS8,UQCRC2,UQCRH
KEGG_P53_SIGNALING_PATHWAY 3.6e-06 6.1e-05 1156 68 10 BID,CASP3,CCNB1,CCNB2,CDK1,CDK2,CHEK1,COP1,RCHY1,SFN

Num: 3 (Pathways: 4 DK: 8)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (8) ADCK2, CAMKK2, CDK13, CSNK1G2, MAST4, NEK6, SCYL3, TP53RK
Light Kinase (16) ALPK1, CLK2, EGFR, MTOR, NLK, PDGFRA, PDK4, PIK3CG, PKN1, PKN2, ROR1, RYK, STK24, STK39, TBRG4, TEK
Non-kinase Count 876
label pval fdr signature geneset overlap hits
KEGG_OXIDATIVE_PHOSPHORYLATION 0.0e+00 3.1e-06 900 131 15 ATP5F1A,ATP5MC1,ATP5MC2,ATP5ME,ATP5PO,COX17,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PPA1,PPA2,UQCRFS1
KEGG_HUNTINGTONS_DISEASE 2.0e-07 1.8e-05 900 180 16 ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,BDNF,COX8A,CREB3L4,IFT57,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,POLR2G,POLR2I,UQCRFS1
KEGG_SELENOAMINO_ACID_METABOLISM 3.0e-07 1.8e-05 900 26 7 AHCY,CBS,GGT5,LCMT2,METTL6,SCLY,SEPHS2
KEGG_PARKINSONS_DISEASE 3.8e-06 1.8e-04 900 128 12 ATP5F1A,ATP5MC1,ATP5MC2,ATP5PO,COX8A,NDUFA7,NDUFB6,NDUFS1,NDUFV1,NDUFV3,PARK7,UQCRFS1

Num: 10 (Pathways: 1 DK: 7)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (7) BRSK2, CDK18, CDKL2, LTK, MAP3K14, STK31, STK33
Light Kinase (15) ACVR1B, AKT3, DAPK3, EPHA4, FES, FYN, GRK5, LCK, MAP3K9, MAP4K5, MERTK, NPR2, PRKG1, TNK1, TNNI3K
Non-kinase Count 714
label pval fdr signature geneset overlap hits
KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION 8e-07 0.00014 736 272 17 ADRA1B,C5AR1,GABBR2,GABRR2,GIPR,GRIA2,GRIK2,GRIN2A,OPRM1,P2RY2,P2RY4,PLG,PRLHR,PTGIR,PTH2R,TBXA2R,THRB

Num: 18 (Pathways: 10 DK: 7)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (7) CDC42BPB, CDK15, ICK, NEK8, NRBP2, STK32C, STK36
Light Kinase (21) ABL1, AXL, DGKA, EIF2AK4, ERBB2, IGF1R, IKBKB, IKBKE, MAP2K5, MAP3K11, MAP3K12, MAPK3, MYLK, NPR1, PIK3CB, PRKD1, ROS1, STK16, STRADA, TRIO, ULK2
Non-kinase Count 976
label pval fdr signature geneset overlap hits
KEGG_FOCAL_ADHESION 0.0e+00 0.0e+00 1004 199 25 ACTN1,ACTN4,BCAR1,CCND3,COL1A1,COL5A2,DOCK1,ERBB2,IGF1R,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,MAPK3,MYLK,PARVB,PDGFC,PIK3CB,PIK3R1,PIK3R2,RAC3,TLN1,VEGFB
KEGG_PATHWAYS_IN_CANCER 0.0e+00 9.0e-07 1004 325 25 ABL1,AR,CDKN2B,ERBB2,FZD6,IGF1R,IKBKB,LAMA3,LAMB1,LAMB2,MAPK3,MECOM,PIAS3,PIK3CB,PIK3R1,PIK3R2,PPARD,RAC3,RXRA,SMAD3,STAT3,STK36,TP53,VEGFB,ZBTB16
KEGG_REGULATION_OF_ACTIN_CYTOSKELETON 0.0e+00 9.0e-07 1004 213 20 ACTN1,ACTN4,ARPC5,BCAR1,CFL1,DOCK1,F2R,ITGA11,ITGB4,ITGB8,MAPK3,MRAS,MYLK,PDGFC,PIK3CB,PIK3R1,PIK3R2,PIP4K2B,RAC3,SSH3
KEGG_ECM_RECEPTOR_INTERACTION 1.0e-07 5.5e-06 1004 84 12 CD36,COL1A1,COL5A2,DAG1,HSPG2,ITGA11,ITGB4,ITGB8,LAMA3,LAMB1,LAMB2,SV2A
KEGG_PANCREATIC_CANCER 2.0e-07 5.5e-06 1004 70 11 ERBB2,IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,RAC3,SMAD3,STAT3,TP53,VEGFB
KEGG_SMALL_CELL_LUNG_CANCER 1.0e-06 3.1e-05 1004 84 11 CDKN2B,IKBKB,LAMA3,LAMB1,LAMB2,PIAS3,PIK3CB,PIK3R1,PIK3R2,RXRA,TP53
KEGG_PROSTATE_CANCER 1.8e-06 4.7e-05 1004 89 11 AR,CREB3L1,ERBB2,IGF1R,IKBKB,MAPK3,PDGFC,PIK3CB,PIK3R1,PIK3R2,TP53
KEGG_PEROXISOME 3.7e-06 8.7e-05 1004 78 10 ABCD1,DDO,DECR2,ECI2,NUDT12,PEX11B,PEX11G,PEX13,PXMP2,SCP2
KEGG_CHRONIC_MYELOID_LEUKEMIA 1.6e-05 3.3e-04 1004 73 9 ABL1,IKBKB,MAPK3,MECOM,PIK3CB,PIK3R1,PIK3R2,SMAD3,TP53
KEGG_ACUTE_MYELOID_LEUKEMIA 1.8e-05 3.3e-04 1004 57 8 IKBKB,MAPK3,PIK3CB,PIK3R1,PIK3R2,PPARD,STAT3,ZBTB16

Num: 19 (Pathways: 1 DK: 7)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (7) CDK17, CLK3, DYRK2, HIPK1, RIOK3, SCYL1, STK19
Light Kinase (23) ABL2, ATM, BRD4, BTK, CAMK2G, CLK1, FER, GRK7, HKDC1, LYN, MAP2K7, MAP4K4, MAPK6, MAPK8, MYLK2, RPS6KA5, SIK1, SIK1B, SMG1, STK10, STK35, TYRO3, WEE1
Non-kinase Count 744
label pval fdr signature geneset overlap hits
KEGG_ENDOCYTOSIS 0 5.2e-06 774 181 16 ACAP2,CHMP4B,CHMP5,CLTB,CLTC,DNM2,GRK7,HGS,HSPA6,HSPA8,PARD3,RAB11FIP2,SH3KBP1,SMURF1,STAM,VPS37A

Num: 5 (Pathways: 7 DK: 6)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (6) ALPK3, CDKL5, NEK10, PAK3, PAK6, WNK3
Light Kinase (13) CKB, DGKB, DMPK, EPHA1, EPHA5, FGR, LIMK2, LRRK2, PKDCC, PRKCD, PRKY, RAF1, TIE1
Non-kinase Count 629
label pval fdr signature geneset overlap hits
KEGG_DRUG_METABOLISM_CYTOCHROME_P450 0.0e+00 4.0e-07 648 72 11 ALDH3A1,CYP2C18,CYP2E1,FMO1,FMO2,FMO3,GSTA1,GSTA2,GSTM2,MGST2,UGT1A6
KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 6.0e-07 6.0e-05 648 76 9 DGKB,INPP5A,INPP5D,INPP5J,INPPL1,PIK3R3,PLCB1,PLCD4,PLCE1
KEGG_AXON_GUIDANCE 1.1e-06 6.6e-05 648 129 11 CXCL12,EPHA1,EPHA5,GNAI1,LIMK2,PAK3,PAK6,PLXNC1,SEMA3B,SEMA3E,SEMA4A
KEGG_COMPLEMENT_AND_COAGULATION_CASCADES 3.2e-06 1.3e-04 648 69 8 C1R,C4A,C4B,CFB,CR1,SERPINA5,SERPINF2,VWF
KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 3.6e-06 1.3e-04 648 70 8 ALDH3A1,CYP2C18,CYP2E1,GSTA1,GSTA2,GSTM2,MGST2,UGT1A6
KEGG_INOSITOL_PHOSPHATE_METABOLISM 6.2e-06 1.9e-04 648 54 7 INPP5A,INPP5J,INPPL1,ISYNA1,PLCB1,PLCD4,PLCE1
KEGG_FOCAL_ADHESION 1.3e-05 3.4e-04 648 199 12 BAD,CAV3,COL1A2,COL3A1,MYL9,PAK3,PAK6,PDGFD,PIK3R3,PPP1CB,RAF1,VWF

Num: 14 (Pathways: 7 DK: 6)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (6) CDK20, CLK4, DYRK3, DYRK4, NEK3, NUAK2
Light Kinase (12) ACVR2B, AURKC, BMPR1B, BRAF, CDK7, CSNK1E, MAP3K20, PIM3, PTK6, RIPK2, TRIB1, TRPM6
Non-kinase Count 536
label pval fdr signature geneset overlap hits
KEGG_PATHWAYS_IN_CANCER 0.0e+00 0.0e+00 554 325 22 BIRC2,BMP2,BRAF,CDKN1B,CSF3R,DVL1,ETS1,FGF2,IKBKG,IL6,ITGA2B,LAMB3,LAMC2,MMP1,NFKB2,NFKBIA,PPARG,PTGS2,SMAD2,STAT5A,TRAF1,VEGFA
KEGG_NOD_LIKE_RECEPTOR_SIGNALING_PATHWAY 0.0e+00 2.0e-07 554 62 10 BIRC2,CXCL1,IKBKG,IL1B,IL6,NFKBIA,NLRC4,NLRP3,RIPK2,TNFAIP3
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 0.0e+00 6.0e-07 554 265 17 ACVR2B,BMP2,BMPR1B,CSF2,CSF3,CSF3R,CXCL1,CXCL10,IL1A,IL1B,IL6,INHBA,LTBR,PRLR,TNFRSF12A,TSLP,VEGFA
KEGG_CIRCADIAN_RHYTHM_MAMMAL 2.0e-07 9.1e-06 554 13 5 BHLHE40,BHLHE41,CSNK1E,NPAS2,PER1
KEGG_SMALL_CELL_LUNG_CANCER 4.0e-07 1.5e-05 554 84 9 BIRC2,CDKN1B,IKBKG,ITGA2B,LAMB3,LAMC2,NFKBIA,PTGS2,TRAF1
KEGG_MAPK_SIGNALING_PATHWAY 1.1e-05 3.3e-04 554 267 13 BRAF,DUSP10,DUSP16,DUSP8,FGF2,GADD45B,IKBKG,IL1A,IL1B,MAP3K20,NFKB2,NGF,RELB
KEGG_RIG_I_LIKE_RECEPTOR_SIGNALING_PATHWAY 1.4e-05 3.8e-04 554 71 7 CXCL10,DDX58,DHX58,IFIH1,IKBKG,ISG15,NFKBIA

Num: 9 (Pathways: 12 DK: 4)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (4) EEF2K, PKMYT1, PRPF4B, RSKR
Light Kinase (23) AKT1, ATR, BUB1B, CDC7, CHUK, CIT, EPHA3, FASTKD1, FASTKD2, FASTKD3, FASTKD5, GRK6, HASPIN, MAP3K7, PBK, PI4K2B, PLK1, PRKDC, RPS6KA1, STRADB, TRIM28, TTK, VRK1
Non-kinase Count 1112
label pval fdr signature geneset overlap hits
KEGG_PYRIMIDINE_METABOLISM 0 0e+00 1139 98 29 CAD,DHODH,DTYMK,DUT,ENTPD6,NME1,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PRIM1,RRM2,TK1,TYMS,UMPS
KEGG_DNA_REPLICATION 0 0e+00 1139 36 20 DNA2,FEN1,LIG1,MCM2,MCM5,MCM6,POLA1,POLA2,POLD1,POLE2,POLE3,PRIM1,RFC2,RFC3,RFC4,RFC5,RNASEH1,RPA1,RPA3,SSBP1
KEGG_PURINE_METABOLISM 0 0e+00 1139 159 34 ADCY3,ENTPD2,ENTPD6,GART,HPRT1,IMPDH1,NME1,NUDT5,PAICS,PDE4A,PDE7A,PNPT1,POLA1,POLA2,POLD1,POLE2,POLE3,POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K,PPAT,PRIM1,PRPS1,PRPS2,RRM2
KEGG_CELL_CYCLE 0 0e+00 1139 124 29 ANAPC1,ANAPC10,ANAPC4,ATR,BUB1B,BUB3,CCNE1,CDC20,CDC45,CDC7,DBF4,E2F4,HDAC2,MAD2L1,MCM2,MCM5,MCM6,ORC1,ORC2,ORC5,PKMYT1,PLK1,PRKDC,PTTG1,SKP2,SMC1A,TFDP1,TGFB2,TTK
KEGG_SPLICEOSOME 0 0e+00 1139 127 28 AQR,CDC5L,DHX15,EFTUD2,HNRNPC,LSM3,LSM6,LSM7,NCBP1,PPIH,PPIL1,PRPF19,PRPF38B,PRPF4,PRPF40A,SF3B4,SNRNP200,SNRNP40,SNRNP70,SNRPC,SNRPD1,SNRPD3,SNRPF,SNRPG,SRSF10,SRSF9,THOC3,TXNL4A
KEGG_MISMATCH_REPAIR 0 0e+00 1139 23 13 EXO1,LIG1,MLH1,MLH3,MSH6,POLD1,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3,SSBP1
KEGG_HOMOLOGOUS_RECOMBINATION 0 0e+00 1139 28 12 BLM,EME1,MRE11,POLD1,RAD51C,RAD54B,RPA1,RPA3,SSBP1,TOP3B,XRCC2,XRCC3
KEGG_RNA_POLYMERASE 0 0e+00 1139 29 12 POLR1A,POLR1B,POLR1C,POLR2B,POLR2D,POLR2F,POLR2J3,POLR2K,POLR3B,POLR3G,POLR3H,POLR3K
KEGG_BASE_EXCISION_REPAIR 0 0e+00 1139 35 12 APEX1,APEX2,FEN1,HMGB1,LIG1,NEIL2,NTHL1,PARP1,POLD1,POLE2,POLE3,TDG
KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 1e-07 1139 44 11 GTF2H3,LIG1,POLD1,POLE2,POLE3,RFC2,RFC3,RFC4,RFC5,RPA1,RPA3
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 0 2e-07 1139 134 17 ANAPC1,ANAPC10,ANAPC4,BRCA1,CDC20,CUL2,FANCL,PRPF19,SAE1,SKP2,UBE2G2,UBE2L3,UBE2N,UBE2NL,UBE2S,UBE3C,VHL
KEGG_OOCYTE_MEIOSIS 0 6e-07 1139 112 15 ADCY3,ANAPC1,ANAPC10,ANAPC4,CCNE1,CDC20,FBXO5,MAD2L1,PKMYT1,PLK1,PPP1CC,PTTG1,RPS6KA1,SGO1,SMC1A

Num: 17 (Pathways: 1 DK: 4)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (4) OBSCN, STK17A, STK17B, TSSK4
Light Kinase (14) BLVRA, GRK3, GRK4, MAP3K1, MAPK13, MET, MYO3B, NTRK3, PDK3, PIK3CD, PRKCI, SNRK, SYK, TNIK
Non-kinase Count 379
label pval fdr signature geneset overlap hits
KEGG_ENDOCYTOSIS 0 0 397 181 14 ACAP1,ARFGAP1,CBLB,CHMP2B,CHMP4C,EHD4,GRK3,GRK4,HLA-B,LDLR,MET,PRKCI,SH3GL3,VPS37B

Num: 21 (Pathways: 0 DK: 3)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (3) POMK, PSKH1, TSSK6
Light Kinase (14) CAMK1, CDK6, CHEK2, DCLK2, LATS1, MAPK12, MAPK14, MOK, PIK3R4, PRKG2, RPS6KA4, RPS6KB2, STK25, TYK2
Non-kinase Count 375
label pval fdr signature geneset overlap hits

Num: 8 (Pathways: 2 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) MKNK2, NIM1K
Light Kinase (5) DYRK1A, MAP3K2, PDK1, PRKAA2, TEC
Non-kinase Count 390
label pval fdr signature geneset overlap hits
KEGG_GLYCOLYSIS_GLUCONEOGENESIS 0.0e+00 3e-07 397 62 9 ALDOA,ENO1,ENO2,GAPDH,GPI,LDHA,PGK1,PKM,TPI1
KEGG_PENTOSE_PHOSPHATE_PATHWAY 2.2e-06 2e-04 397 27 5 ALDOA,GPI,PGD,TALDO1,TKT

Num: 13 (Pathways: 0 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) BCKDK, TBCK
Light Kinase (1) DDR1
Non-kinase Count 118
label pval fdr signature geneset overlap hits

Num: 15 (Pathways: 0 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) PI4KA, RNASEL
Light Kinase (14) BMPR2, CDK5, EPHA10, FPGT-TNNI3K, JAK3, MAP2K4, PDGFRB, PDK2, PIK3C2A, PRKD3, PTK7, ROCK1, SPEG, TRIM24
Non-kinase Count 334
label pval fdr signature geneset overlap hits

Num: 16 (Pathways: 1 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) MAP3K21, STK40
Light Kinase (13) AURKA, CDK4, CSNK1A1, EPHA2, HK2, IRAK2, MAP2K1, MAPKAPK3, MAPKAPK5, PIM2, PLK3, TAF1, TRIB2
Non-kinase Count 573
label pval fdr signature geneset overlap hits
KEGG_AMINOACYL_TRNA_BIOSYNTHESIS 0 2e-07 588 41 9 AARS1,CARS1,DARS1,EARS2,GARS1,IARS1,LARS1,PSTK,SARS1

Num: 20 (Pathways: 15 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) PKN3, TSSK3
Light Kinase (14) AKT2, BMPR1A, DGKH, DGKI, HIPK2, IRAK1, MAP3K3, MAP4K3, PDPK1, PIK3CA, RIPK1, SIK2, TRRAP, WNK1
Non-kinase Count 276
label pval fdr signature geneset overlap hits
KEGG_ENDOMETRIAL_CANCER 0.0e+00 2.8e-06 292 52 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_NON_SMALL_CELL_LUNG_CANCER 0.0e+00 2.8e-06 292 54 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_PROSTATE_CANCER 1.0e-07 2.9e-06 292 89 8 AKT2,EP300,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_NEUROTROPHIN_SIGNALING_PATHWAY 1.0e-07 2.9e-06 292 126 9 AKT2,HRAS,IRAK1,MAP3K3,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_INSULIN_SIGNALING_PATHWAY 1.0e-07 4.8e-06 292 137 9 AKT2,HRAS,NRAS,PDPK1,PHKB,PIK3CA,PRKAR1A,SOS1,SOS2
KEGG_RENAL_CELL_CARCINOMA 2.0e-07 5.8e-06 292 70 7 AKT2,EP300,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_FC_EPSILON_RI_SIGNALING_PATHWAY 4.0e-07 1.2e-05 292 79 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_ACUTE_MYELOID_LEUKEMIA 1.1e-06 2.5e-05 292 57 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_GLIOMA 2.3e-06 4.8e-05 292 65 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_FOCAL_ADHESION 3.0e-06 5.5e-05 292 199 9 AKT2,HRAS,ITGA10,PARVA,PDPK1,PIK3CA,SOS1,SOS2,ZYX
KEGG_T_CELL_RECEPTOR_SIGNALING_PATHWAY 3.6e-06 6.1e-05 292 108 7 AKT2,HRAS,NRAS,PDPK1,PIK3CA,SOS1,SOS2
KEGG_CHRONIC_MYELOID_LEUKEMIA 4.6e-06 7.2e-05 292 73 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_B_CELL_RECEPTOR_SIGNALING_PATHWAY 5.4e-06 7.7e-05 292 75 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_ERBB_SIGNALING_PATHWAY 1.3e-05 1.7e-04 292 87 6 AKT2,HRAS,NRAS,PIK3CA,SOS1,SOS2
KEGG_GNRH_SIGNALING_PATHWAY 3.0e-05 3.7e-04 292 101 6 HRAS,MAP3K3,MMP14,NRAS,SOS1,SOS2

Num: 22 (Pathways: 4 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) CSNK2A3, PRKACB
Light Kinase (3) DGKQ, ERBB3, RPS6KA6
Non-kinase Count 370
label pval fdr signature geneset overlap hits
KEGG_ALZHEIMERS_DISEASE 0 0e+00 375 165 14 ATP5F1C,ATP5F1E,ATP5PD,CALM1,COX7A2,COX7C,FADD,NDUFA4L2,NDUFB1,NDUFB5,PPP3CB,UQCR11,UQCRB,UQCRQ
KEGG_HUNTINGTONS_DISEASE 0 0e+00 375 180 14 ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,CREB3L2,DNAL4,NDUFA4L2,NDUFB1,NDUFB5,POLR2E,UQCR11,UQCRB,UQCRQ
KEGG_OXIDATIVE_PHOSPHORYLATION 0 0e+00 375 131 12 ATP5F1C,ATP5F1E,ATP5PD,ATP6V0D1,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ
KEGG_PARKINSONS_DISEASE 0 2e-07 375 128 11 ATP5F1C,ATP5F1E,ATP5PD,COX7A2,COX7C,NDUFA4L2,NDUFB1,NDUFB5,UQCR11,UQCRB,UQCRQ

Num: 23 (Pathways: 4 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) CDC42BPA, CDK10
Light Kinase (2) FASTK, WNK4
Non-kinase Count 200
label pval fdr signature geneset overlap hits
KEGG_OXIDATIVE_PHOSPHORYLATION 0 0 204 131 12 ATP5MC3,ATP5MF,COX15,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB7,NDUFS5,NDUFS6,SDHA,UQCR10
KEGG_ALZHEIMERS_DISEASE 0 0 204 165 12 ATP5MC3,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB7,NDUFS5,NDUFS6,PPP3CA,SDHA,UQCR10
KEGG_PARKINSONS_DISEASE 0 0 204 128 10 ATP5MC3,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB7,NDUFS5,NDUFS6,SDHA,UQCR10
KEGG_HUNTINGTONS_DISEASE 0 0 204 180 11 ATP5MC3,CASP8,COX7B,NDUFA2,NDUFA3,NDUFB10,NDUFB7,NDUFS5,NDUFS6,SDHA,UQCR10

Num: 24 (Pathways: 0 DK: 2)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (2) ALPK2, PXK
Light Kinase (4) BRDT, ERN1, MAK, PRKCE
Non-kinase Count 248
label pval fdr signature geneset overlap hits

Num: 6 (Pathways: 0 DK: 1)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (1) CDK14
Light Kinase (3) AATK, OXSR1, RIPK4
Non-kinase Count 171
label pval fdr signature geneset overlap hits

Num: 25 (Pathways: 0 DK: 0)

The blue dots indicate the mean fold change, while the red dots indicate the overall means. The boxplots show the distribution of all the genes in the cluster. The kinases are highlighted with the lines.

gene_type info
Dark Kinase (0)
Light Kinase (2) EPHB4, SRC
Non-kinase Count 101
label pval fdr signature geneset overlap hits